Twelfth of the nineteen Kagero-class destroyers, Isokaze was laid down in 1938. Commissioned 30 November, 1940, she served as a carrier escort from the outbreak of War in December, 1941 until the Midway debacle the following June. Isokaze participated in the Guadalcanal campaign for its duration, but only saw minor action, mostly from air attacks. She continued operations in the Solomons until November, 1943, when she struck a mine. Isokaze returned to Japan for repairs, and subsequently participated in the Battles of the Philippine Sea and Leyte Gulf, again escorting carriers. Her final mission was as escort for the kamikaze run of the battleship Yamato in April, 1945. Isokaze was disabled by air attack on the 7th, and scuttled.